Richard "Richie" Twat and Edward "Eddie" Elizabeth Ndingombaba are two losers who run Guest House Paradiso, the worst hotel in the UK. Guest House Paradiso is next-door to a nuclear-power plant, The chef is a illegal immigrant and the waiter escaped from a mental-health facility. Once the guests check in, they are dying to check out. Richie and Eddie's luck is about to change when Italian film star Gina Carbonara checks in, attempting to hide from her horrible fiancé Gino Bolognese, and the Nice family checks in and Richie discovers that Mr. and Mrs. Nice have a rubber bra and underpants. But all hell breaks loose when Richie and Eddie serve radioactive fish to the guests for supper and the guests become very ill; meanwhile, Gino has tracked down Gina.
